Membrane bridging by Munc13-1 is crucial for neurotransmitter release

Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-terminal region encompassing the C(1), C(2)B, MUN and C(2)C domains of Munc13-1 (C(1)C(2)BMUNC(2)C) bridges the synaptic vesicle and plasma membranes through interactions involving the C(2)C domain and the C(1...

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Pubblicato in:eLife
Autori principali: Quade, Bradley, Camacho, Marcial, Zhao, Xiaowei, Orlando, Marta, Trimbuch, Thorsten, Xu, Junjie, Li, Wei, Nicastro, Daniela, Rosenmund, Christian, Rizo, Josep
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407922/
https://ncbi.nlm.nih.gov/pubmed/30816091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42806
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