Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci

Cystic Fibrosis (CF) exhibits morbidity in several organs, including progressive lung disease in all patients and intestinal obstruction at birth (meconium ileus) in ~15%. Individuals with the same causal CFTR mutations show variable disease presentation which is partly attributed to modifier genes....

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Gong, Jiafen, Wang, Fan, Xiao, Bowei, Panjwani, Naim, Lin, Fan, Keenan, Katherine, Avolio, Julie, Esmaeili, Mohsen, Zhang, Lin, He, Gengming, Soave, David, Mastromatteo, Scott, Baskurt, Zeynep, Kim, Sangook, O’Neal, Wanda K., Polineni, Deepika, Blackman, Scott M., Corvol, Harriet, Cutting, Garry R., Drumm, Mitchell, Knowles, Michael R., Rommens, Johanna M., Sun, Lei, Strug, Lisa J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407791/
https://ncbi.nlm.nih.gov/pubmed/30807572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008007
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