A Joint Location-Scale Test Improves Power to Detect Associated SNPs, Gene Sets, and Pathways

Gene-based, pathway, and other multivariate association methods are motivated by the possibility of GxG and GxE interactions; however, accounting for such interactions is limited by the challenges associated with adequate modeling information. Here we propose an easy-to-implement joint location-scal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Hum Genet
Prif Awduron: Soave, David, Corvol, Harriet, Panjwani, Naim, Gong, Jiafen, Li, Weili, Boëlle, Pierre-Yves, Durie, Peter R., Paterson, Andrew D., Rommens, Johanna M., Strug, Lisa J., Sun, Lei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572492/
https://ncbi.nlm.nih.gov/pubmed/26140448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.05.015
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