The human gut bacterial genotoxin colibactin alkylates DNA

Certain Escherichia coli strains residing in the human gut produce colibactin, a small molecule genotoxin implicated in colorectal cancer pathogenesis. However, colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects have remained unknown for over a decade. Here,...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Science
मुख्य लेखकों: Wilson, Matthew R., Jiang, Yindi, Villalta, Peter W., Stornetta, Alessia, Boudreau, Paul D., Carrá, Andrea, Brennan, Caitlin A., Chun, Eunyoung, Ngo, Lizzie, Samson, Leona D., Engelward, Bevin P., Garrett, Wendy S., Balbo, Silvia, Balskus, Emily P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407708/
https://ncbi.nlm.nih.gov/pubmed/30765538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7785
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