MATE transport of the E. coli-derived genotoxin colibactin

Various forms of cancer have been linked to the carcinogenic activities of microorganisms(1–3). The virulent gene island polyketide synthase (pks) produces the secondary metabolite colibactin, a genotoxic molecule(s) causing double-stranded DNA breaks(4) and enhanced colorectal cancer development(5,...

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Bibliografiska uppgifter
I publikationen:Nat Microbiol
Huvudupphovsmän: Mousa, Jarrod J., Yang, Ye, Tomkovich, Sarah, Shima, Ayaka, Newsome, Rachel C., Tripathi, Prabhanshu, Oswald, Eric, Bruner, Steven D., Jobin, Christian
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704960/
https://ncbi.nlm.nih.gov/pubmed/27571755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmicrobiol.2015.9
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