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The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells. Colibactin-producing strains are found associated with colorectal cancer biopsy s...
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| Publicado en: | mSphere |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6796968/ https://ncbi.nlm.nih.gov/pubmed/31578245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00414-19 |
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