The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin

Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells. Colibactin-producing strains are found associated with colorectal cancer biopsy s...

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Publicado en:mSphere
Main Authors: Chagneau, Camille V., Garcie, Christophe, Bossuet-Greif, Nadège, Tronnet, Sophie, Brachmann, Alexander O., Piel, Jörn, Nougayrède, Jean-Philippe, Martin, Patricia, Oswald, Eric
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796968/
https://ncbi.nlm.nih.gov/pubmed/31578245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00414-19
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