The human gut bacterial genotoxin colibactin alkylates DNA

Certain Escherichia coli strains residing in the human gut produce colibactin, a small molecule genotoxin implicated in colorectal cancer pathogenesis. However, colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects have remained unknown for over a decade. Here,...

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Udgivet i:Science
Main Authors: Wilson, Matthew R., Jiang, Yindi, Villalta, Peter W., Stornetta, Alessia, Boudreau, Paul D., Carrá, Andrea, Brennan, Caitlin A., Chun, Eunyoung, Ngo, Lizzie, Samson, Leona D., Engelward, Bevin P., Garrett, Wendy S., Balbo, Silvia, Balskus, Emily P.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407708/
https://ncbi.nlm.nih.gov/pubmed/30765538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7785
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