The human gut bacterial genotoxin colibactin alkylates DNA

Certain Escherichia coli strains residing in the human gut produce colibactin, a small molecule genotoxin implicated in colorectal cancer pathogenesis. However, colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects have remained unknown for over a decade. Here,...

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Gepubliceerd in:Science
Hoofdauteurs: Wilson, Matthew R., Jiang, Yindi, Villalta, Peter W., Stornetta, Alessia, Boudreau, Paul D., Carrá, Andrea, Brennan, Caitlin A., Chun, Eunyoung, Ngo, Lizzie, Samson, Leona D., Engelward, Bevin P., Garrett, Wendy S., Balbo, Silvia, Balskus, Emily P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407708/
https://ncbi.nlm.nih.gov/pubmed/30765538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7785
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