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The human gut bacterial genotoxin colibactin alkylates DNA
Certain Escherichia coli strains residing in the human gut produce colibactin, a small molecule genotoxin implicated in colorectal cancer pathogenesis. However, colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects have remained unknown for over a decade. Here,...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6407708/ https://ncbi.nlm.nih.gov/pubmed/30765538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7785 |
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