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The reactivity of an unusual amidase may explain colibactin’s DNA cross-linking activity
Certain commensal and pathogenic bacteria produce colibactin, a small molecule genotoxin that causes interstrand cross-links in host cell DNA. Though colibactin alkylates DNA, the molecular basis for cross-link formation is unclear. Here, we report that the colibactin biosynthetic enzyme ClbL is an...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6728428/ https://ncbi.nlm.nih.gov/pubmed/31251062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b02453 |
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