Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

The most challenging issue facing peptide drug development is producing a molecule with optimal physical properties while maintaining target binding affinity. Masking peptides with protecting groups that can be removed inside the cell, produces a cell-permeable peptide, which theoretically can maint...

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Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Huo, Yuantao, Buckton, Laura K., Bennett, Jack L., Smith, Eloise C., Byrne, Frances L., Hoehn, Kyle L., Rahimi, Marwa N., McAlpine, Shelli R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407599/
https://ncbi.nlm.nih.gov/pubmed/30822267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1580276
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