Structure−Activity Relationship Studies of 6α- and 6β-Indolylacetamidonaltrexamine Derivatives as Bitopic Mu Opioid Receptor Modulators and Elaboration of the “Message-Address Concept” To Comprehend Their Functional Conversion

Structure−activity relationship (SAR) studies of numerous opioid ligands have shown that introduction of a methyl or ethyl group on the tertiary amino group at position 17 of the epoxymorphinan skeleton generally results in a mu opioid receptor (MOR) agonist while introduction of a cyclopropylmethyl...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Obeng, Samuel, Wang, Huiqun, Jali, Abdulmajeed, Stevens, David L., Akbarali, Hamid I., Dewey, William L., Selley, Dana E., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405326/
https://ncbi.nlm.nih.gov/pubmed/30156823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00349
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