A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

Overexpression of recombinant proteins in bacteria may lead to their aggregation and deposition in inclusion bodies. Since the conformational properties of proteins in inclusion bodies exhibit many of the characteristics typical of amyloid fibrils. Based on these findings, we hypothesize that the ra...

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Vydáno v:Sci Rep
Hlavní autoři: Sanagavarapu, Kalyani, Nüske, Elisabeth, Nasir, Irem, Meisl, Georg, Immink, Jasper N., Sormanni, Pietro, Vendruscolo, Michele, Knowles, Tuomas P. J., Malmendal, Anders, Cabaleiro-Lago, Celia, Linse, Sara
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403284/
https://ncbi.nlm.nih.gov/pubmed/30842594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39216-z
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