A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

Overexpression of recombinant proteins in bacteria may lead to their aggregation and deposition in inclusion bodies. Since the conformational properties of proteins in inclusion bodies exhibit many of the characteristics typical of amyloid fibrils. Based on these findings, we hypothesize that the ra...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sanagavarapu, Kalyani, Nüske, Elisabeth, Nasir, Irem, Meisl, Georg, Immink, Jasper N., Sormanni, Pietro, Vendruscolo, Michele, Knowles, Tuomas P. J., Malmendal, Anders, Cabaleiro-Lago, Celia, Linse, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403284/
https://ncbi.nlm.nih.gov/pubmed/30842594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39216-z
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