Nuclear Translocation of Calmodulin in Pathological Cardiac Hypertrophy Originates from Ryanodine Receptor bound Calmodulin

In cardiac myocytes Calmodulin (CaM) bound to the ryanodine receptor (RyR2) constitutes a large pool of total myocyte CaM, but the CaM-RyR2 affinity is reduced in pathological conditions. Knock-in mice expressing RyR2 unable to bind CaM also developed hypertrophy and early death. However, it is unkn...

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Published in:J Mol Cell Cardiol
Main Authors: Oda, Tetsuro, Yamamoto, Takeshi, Kato, Takayoshi, Uchinoumi, Hitoshi, Fukui, Go, Hamada, Yoriomi, Nanno, Takuma, Ishiguchi, Hironori, Nakamura, Yoshihide, Okamoto, Yoko, Kono, Michiaki, Okuda, Shinichi, Kobayashi, Shigeki, Bers, Donald M., Yano, Masafumi
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402808/
https://ncbi.nlm.nih.gov/pubmed/30359562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.10.011
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