Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin Cytoskeleton

APOL1-miR193a axis participates in the preservation of molecular phenotype of differentiated podocytes (DPDs). We examined the hypothesis that APOL1 (G0) preserves, but APOL1 risk alleles (G1 and G2) disrupt APOL1-miR193a axis in DPDs. DPDG0s displayed down-regulation of miR193a, but upregulation of...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kumar, Vinod, Paliwal, Nitpriya, Ayasolla, Kamesh, Vashistha, Himanshu, Jha, Alok, Chandel, Nirupama, Chowdhary, Sheetal, Saleem, Moin A., Malhotra, Ashwani, Chander, Praveen N., Skorecki, Karl, Singhal, Pravin C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401370/
https://ncbi.nlm.nih.gov/pubmed/30837512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39376-y
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