Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu

The loss of podocyte (PD) molecular phenotype is an important feature of diabetic podocytopathy. We hypothesized that high glucose (HG) induces dedifferentiation in differentiated podocytes (DPDs) through alterations in the apolipoprotein (APO) L1-microRNA (miR) 193a axis. HG-induced DPD dedifferent...

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Vydáno v:Am J Physiol Renal Physiol
Hlavní autoři: Mishra, Abheepsa, Ayasolla, Kamesh, Kumar, Vinod, Lan, Xiqian, Vashistha, Himanshu, Aslam, Rukhsana, Hussain, Ali, Chowdhary, Sheetal, Marashi Shoshtari, Shadafarin, Paliwal, Nitpriya, Popik, Waldemar, Saleem, Moin A., Malhotra, Ashwani, Meggs, Leonard G., Skorecki, Karl, Singhal, Pravin C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031922/
https://ncbi.nlm.nih.gov/pubmed/29357419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00541.2017
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