Disrupted apolipoprotein L1-miR193a axis dedifferentiates podocytes through autophagy blockade in an APOL1 risk milieu

We hypothesized that a functional apolipoprotein LI (APOL1)-miR193a axis (inverse relationship) preserves, but disruption alters, the podocyte molecular phenotype through the modulation of autophagy flux. Podocyte-expressing APOL1G0 (G0-podocytes) showed downregulation but podocyte-expressing APOL1G...

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Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Kumar, Vinod, Ayasolla, Kamesh, Jha, Alok, Mishra, Abheepsa, Vashistha, Himanshu, Lan, Xiqian, Qayyum, Maleeha, Chinnapaka, Sushma, Purohit, Richa, Mikulak, Joanna, Saleem, Moin A., Malhotra, Ashwani, Skorecki, Karl, Singhal, Pravin C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732421/
https://ncbi.nlm.nih.gov/pubmed/31116585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00538.2018
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