Alterations in Plasma Membrane Ion Channel Structures Stimulate NLRP3 Inflammasomes Activation in APOL1 Risk Milieu

We evaluated alterations in the structural configurations of channels and activation of NLRP3 inflammasomes formation in APOL1 risk and non-risk milieus. APOL1G1- and APOL1G2- expressing podocytes displayed enhanced K(+) efflux, induction of pyroptosis, and escalated transcription of interleukin (IL...

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Bibliografske podrobnosti
izdano v:FEBS J
Main Authors: Jha, Alok, Kumar, Vinod, Haque, Shabirul, Ayasolla, Kamesh, Saha, Shourav, Lan, Xiqian, Malhotra, Ashwani, Saleem, Moin A., Skorecki, Karl, Singhal, Pravin C.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298666/
https://ncbi.nlm.nih.gov/pubmed/31714001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15133
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