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MEK2 negatively Regulates LPS Mediated IL-1β Production Through HIF-1α Expression
LPS activated macrophages require metabolic reprogramming and glucose uptake mediated by hypoxia inducible factor (HIF-1) α and glucose transporter (Glut)1 expression for proinflammatory cytokine production, especially IL-1β. This process is tightly regulated through activation of mitogen-activated...
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| Veröffentlicht in: | J Immunol |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6401293/ https://ncbi.nlm.nih.gov/pubmed/30710049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801477 |
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