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MEK2 negatively Regulates LPS Mediated IL-1β Production Through HIF-1α Expression

LPS activated macrophages require metabolic reprogramming and glucose uptake mediated by hypoxia inducible factor (HIF-1) α and glucose transporter (Glut)1 expression for proinflammatory cytokine production, especially IL-1β. This process is tightly regulated through activation of mitogen-activated...

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Podrobná bibliografie
Vydáno v:J Immunol
Hlavní autoři: Talwar, Harvinder, Bouhamdan, Mohamad, Bauerfeld, Christian, Talreja, Jaya, Aoidi, Rifdat, Houde, Nicolas, Charron, Jean, Samavati, Lobelia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401293/
https://ncbi.nlm.nih.gov/pubmed/30710049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801477
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