MEK1 Dependent and Independent ERK Activation Regulates IL-10 and IL-12 Production in Bone Marrow Derived Macrophages

The mitogen activated protein kinases ERK1/2 play an important role in response to toll like receptor (TLR) activation and cytokine production, including IL-10 and IL-12. Here, we examined the role of MEK1 in ERK1/2 activation in response to TLR4 agonist by using bone marrow-derived macrophages (BMD...

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Veröffentlicht in:Cell Signal
Hauptverfasser: Bouhamdan, Mohamad, Bauerfeld, Christian, Talreja, Jaya, Beuret, Laurent, Charron, Jean, Samavati, Lobelia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540637/
https://ncbi.nlm.nih.gov/pubmed/26208884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.07.015
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