Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire

The αβ T cell receptor (TCR) repertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly generated pre-selection repertoire is not known. Here we perform comparative repertoire sequence analyses of pre-selection and post-selection...

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Publicat a:Nat Commun
Autors principals: Lu, Jinghua, Van Laethem, François, Bhattacharya, Abhisek, Craveiro, Marco, Saba, Ingrid, Chu, Jonathan, Love, Nicholas C., Tikhonova, Anastasia, Radaev, Sergei, Sun, Xiaoping, Ko, Annette, Arnon, Tomer, Shifrut, Eric, Friedman, Nir, Weng, Nan-Ping, Singer, Alfred, Sun, Peter D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399321/
https://ncbi.nlm.nih.gov/pubmed/30833553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08906-7
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