Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid

A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology that precedes neuronal death and symptom onset, would be a much-needed prognostic biomarker. With direct access to the brain interstitial fluid, the cerebrospinal fluid (CSF) is a potential source of synapse...

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Bibliografske podrobnosti
izdano v:Mol Cell Proteomics
Main Authors: Lleó, Alberto, Núñez-Llaves, Raúl, Alcolea, Daniel, Chiva, Cristina, Balateu-Paños, Daniel, Colom-Cadena, Martí, Gomez-Giro, Gemma, Muñoz, Laia, Querol-Vilaseca, Marta, Pegueroles, Jordi, Rami, Lorena, Lladó, Albert, Molinuevo, José L., Tainta, Mikel, Clarimón, Jordi, Spires-Jones, Tara, Blesa, Rafael, Fortea, Juan, Martínez-Lage, Pablo, Sánchez-Valle, Raquel, Sabidó, Eduard, Bayés, Àlex, Belbin, Olivia
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398205/
https://ncbi.nlm.nih.gov/pubmed/30606734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.001290
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