Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis

OBJECTIVE: To identify transcriptomic changes, neuropathologic correlates, and cellular subpopulations in the motor cortex of sporadic amyotrophic lateral sclerosis (ALS). METHODS: We performed massive RNA sequencing of the motor cortex of patients with ALS (n = 11) and healthy controls (HCs; n = 8)...

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Detalhes bibliográficos
Publicado no:Neurol Neuroimmunol Neuroinflamm
Main Authors: Dols-Icardo, Oriol, Montal, Víctor, Sirisi, Sònia, López-Pernas, Gema, Cervera-Carles, Laura, Querol-Vilaseca, Marta, Muñoz, Laia, Belbin, Olivia, Alcolea, Daniel, Molina-Porcel, Laura, Pegueroles, Jordi, Turón-Sans, Janina, Blesa, Rafael, Lleó, Alberto, Fortea, Juan, Rojas-García, Ricard, Clarimón, Jordi
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371375/
https://ncbi.nlm.nih.gov/pubmed/32669313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000829
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