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Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences

Fluorescent protein reporter genes are widely used to identify and sort murine pancreatic β-cells. In this study, we compared use of the MIP-GFP transgene, which exhibits aberrant expression of human growth hormone (hGH), with a newly derived Ins2(Apple) allele that lacks hGH expression on the expre...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Stancill, Jennifer S., Osipovich, Anna B., Cartailler, Jean-Philippe, Magnuson, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397359/
https://ncbi.nlm.nih.gov/pubmed/30532991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00229.2018
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