Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes

We used mice lacking Abcc8, a key component of the β-cell K(ATP)-channel, to analyze the effects of a sustained elevation in the intracellular Ca(2+) concentration ([Ca(2+)](i)) on β-cell identity and gene expression. Lineage tracing analysis revealed the conversion of β-cells lacking Abcc8 into pan...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Stancill, Jennifer S., Cartailler, Jean-Philippe, Clayton, Hannah W., O’Connor, James T., Dickerson, Matthew T., Dadi, Prasanna K., Osipovich, Anna B., Jacobson, David A., Magnuson, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2017
Soggetti:
Islet Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521870/
https://ncbi.nlm.nih.gov/pubmed/28550109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1355
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