Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1(G93A) Model

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting both the upper and lower motor neurons (MNs), with no effective treatment currently available. Early pathological events in ALS include perturbations in axonal transport (AT), formation of toxic protein aggregates and...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Ionescu, Ariel, Gradus, Tal, Altman, Topaz, Maimon, Roy, Saraf Avraham, Noi, Geva, Michal, Hayden, Michael, Perlson, Eran
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397200/
https://ncbi.nlm.nih.gov/pubmed/30824685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1451-2
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