Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1(G93A) Model

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting both the upper and lower motor neurons (MNs), with no effective treatment currently available. Early pathological events in ALS include perturbations in axonal transport (AT), formation of toxic protein aggregates and...

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Pubblicato in:Cell Death Dis
Autori principali: Ionescu, Ariel, Gradus, Tal, Altman, Topaz, Maimon, Roy, Saraf Avraham, Noi, Geva, Michal, Hayden, Michael, Perlson, Eran
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397200/
https://ncbi.nlm.nih.gov/pubmed/30824685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1451-2
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