Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1(G93A) Model

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting both the upper and lower motor neurons (MNs), with no effective treatment currently available. Early pathological events in ALS include perturbations in axonal transport (AT), formation of toxic protein aggregates and...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Ionescu, Ariel, Gradus, Tal, Altman, Topaz, Maimon, Roy, Saraf Avraham, Noi, Geva, Michal, Hayden, Michael, Perlson, Eran
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397200/
https://ncbi.nlm.nih.gov/pubmed/30824685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1451-2
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