Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment

Osteoclasts are multinucleated cells responsible for bone resorption. The differentiation of osteoclasts from bone marrow macrophages (BMMs) is induced by receptor activator of NF-κB ligand (RANKL). Osteoprotegerin (OPG), a decoy receptor of RANKL, inhibits osteoclastogenesis by blocking RANKL signa...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Ochiai, Nagahiro, Nakachi, Yutaka, Yokoo, Tomotaka, Ichihara, Takahiro, Eriksson, Tore, Yonemoto, Yuki, Kato, Takehiko, Ogata, Hitoshi, Fujimoto, Natsuko, Kobayashi, Yasuhiro, Udagawa, Nobuyuki, Kaku, Shinsuke, Ueki, Tomokazu, Okazaki, Yasushi, Takahashi, Naoyuki, Suda, Tatsuo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397181/
https://ncbi.nlm.nih.gov/pubmed/30854478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0334-5
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