Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment

Osteoclasts are multinucleated cells responsible for bone resorption. The differentiation of osteoclasts from bone marrow macrophages (BMMs) is induced by receptor activator of NF-κB ligand (RANKL). Osteoprotegerin (OPG), a decoy receptor of RANKL, inhibits osteoclastogenesis by blocking RANKL signa...

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Bibliografiset tiedot
Julkaisussa:Commun Biol
Päätekijät: Ochiai, Nagahiro, Nakachi, Yutaka, Yokoo, Tomotaka, Ichihara, Takahiro, Eriksson, Tore, Yonemoto, Yuki, Kato, Takehiko, Ogata, Hitoshi, Fujimoto, Natsuko, Kobayashi, Yasuhiro, Udagawa, Nobuyuki, Kaku, Shinsuke, Ueki, Tomokazu, Okazaki, Yasushi, Takahashi, Naoyuki, Suda, Tatsuo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397181/
https://ncbi.nlm.nih.gov/pubmed/30854478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0334-5
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