Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment

Osteoclasts are multinucleated cells responsible for bone resorption. The differentiation of osteoclasts from bone marrow macrophages (BMMs) is induced by receptor activator of NF-κB ligand (RANKL). Osteoprotegerin (OPG), a decoy receptor of RANKL, inhibits osteoclastogenesis by blocking RANKL signa...

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Pubblicato in:Commun Biol
Autori principali: Ochiai, Nagahiro, Nakachi, Yutaka, Yokoo, Tomotaka, Ichihara, Takahiro, Eriksson, Tore, Yonemoto, Yuki, Kato, Takehiko, Ogata, Hitoshi, Fujimoto, Natsuko, Kobayashi, Yasuhiro, Udagawa, Nobuyuki, Kaku, Shinsuke, Ueki, Tomokazu, Okazaki, Yasushi, Takahashi, Naoyuki, Suda, Tatsuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397181/
https://ncbi.nlm.nih.gov/pubmed/30854478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0334-5
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