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The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi
Although the malfunction of HtrA2/Omi leads to Parkinson’s disease (PD), the underlying mechanism has remained unknown. Here, we showed that HtrA2/Omi specifically removed oligomeric α-Syn but not monomeric α-Syn to protect oligomeric α-Syn-induced neurodegeneration. Experiments using mnd2 mice indi...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7093540/ https://ncbi.nlm.nih.gov/pubmed/32210343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62309-z |
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