A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases

Accumulating evidence indicates that a wide range of E3 ubiquitin ligases are involved in the development of many human diseases. Searching for small-molecule modulators of these E3 ubiquitin ligases is emerging as a promising drug discovery strategy. Here, we report the development of a cell-based...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Tian, Maoyuan, Zeng, Taoling, Liu, Mingdong, Han, Shang, Lin, Huayue, Lin, Qi, Li, Li, Jiang, Tingting, Li, Gao, Lin, Hong, Zhang, Ting, Kang, Qiaofeng, Deng, Xianming, Wang, Hong-Rui
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Methods and Resources
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393603/
https://ncbi.nlm.nih.gov/pubmed/30587574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003822
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