Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase

Selective protein degradation by the ubiquitin-proteasome system (UPS) is involved in all cellular processes. However, the substrates and specificity of most UPS components are not well understood. Here we systematically characterized the UPS in Saccharomyces cerevisiae. Using fluorescent timers, we...

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Bibliografski detalji
Izdano u:Mol Cell
Glavni autori: Kong, Ka-Yiu Edwin, Fischer, Bernd, Meurer, Matthias, Kats, Ilia, Li, Zhaoyan, Rühle, Frank, Barry, Joseph D., Kirrmaier, Daniel, Chevyreva, Veronika, San Luis, Bryan-Joseph, Costanzo, Michael, Huber, Wolfgang, Andrews, Brenda J., Boone, Charles, Knop, Michael, Khmelinskii, Anton
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2021
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189435/
https://ncbi.nlm.nih.gov/pubmed/33974913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.018
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