Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase

Selective protein degradation by the ubiquitin-proteasome system (UPS) is involved in all cellular processes. However, the substrates and specificity of most UPS components are not well understood. Here we systematically characterized the UPS in Saccharomyces cerevisiae. Using fluorescent timers, we...

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Vydáno v:Mol Cell
Hlavní autoři: Kong, Ka-Yiu Edwin, Fischer, Bernd, Meurer, Matthias, Kats, Ilia, Li, Zhaoyan, Rühle, Frank, Barry, Joseph D., Kirrmaier, Daniel, Chevyreva, Veronika, San Luis, Bryan-Joseph, Costanzo, Michael, Huber, Wolfgang, Andrews, Brenda J., Boone, Charles, Knop, Michael, Khmelinskii, Anton
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189435/
https://ncbi.nlm.nih.gov/pubmed/33974913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.018
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