Sequence Variations in pxr (nr1i2) From Zebrafish (Danio rerio) Strains Affect Nuclear Receptor Function

Regulators of biotransformation are of particular interest in pharmacology and toxicology, determining in part the metabolism, disposition, and toxicity of chemicals. The nuclear receptor NR1I2 (pregnane X receptor, PXR) is a prominent xenosensor that regulates the expression of biotransformation en...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Lille-Langøy, Roger, Karlsen, Odd André, Myklebust, Line Merethe, Goldstone, Jared V, Mork-Jansson, Astrid, Male, Rune, Blumberg, Bruce, Stegeman, John J, Goksøyr, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Nuclear Receptor Function in Zebrafish
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390661/
https://ncbi.nlm.nih.gov/pubmed/30371853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy269
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