Sequence Variations in pxr (nr1i2) From Zebrafish (Danio rerio) Strains Affect Nuclear Receptor Function

Regulators of biotransformation are of particular interest in pharmacology and toxicology, determining in part the metabolism, disposition, and toxicity of chemicals. The nuclear receptor NR1I2 (pregnane X receptor, PXR) is a prominent xenosensor that regulates the expression of biotransformation en...

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Vydáno v:Toxicol Sci
Hlavní autoři: Lille-Langøy, Roger, Karlsen, Odd André, Myklebust, Line Merethe, Goldstone, Jared V, Mork-Jansson, Astrid, Male, Rune, Blumberg, Bruce, Stegeman, John J, Goksøyr, Anders
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Nuclear Receptor Function in Zebrafish
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390661/
https://ncbi.nlm.nih.gov/pubmed/30371853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy269
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