Sequence Variations in pxr (nr1i2) From Zebrafish (Danio rerio) Strains Affect Nuclear Receptor Function

Regulators of biotransformation are of particular interest in pharmacology and toxicology, determining in part the metabolism, disposition, and toxicity of chemicals. The nuclear receptor NR1I2 (pregnane X receptor, PXR) is a prominent xenosensor that regulates the expression of biotransformation en...

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Bibliografski detalji
Izdano u:Toxicol Sci
Glavni autori: Lille-Langøy, Roger, Karlsen, Odd André, Myklebust, Line Merethe, Goldstone, Jared V, Mork-Jansson, Astrid, Male, Rune, Blumberg, Bruce, Stegeman, John J, Goksøyr, Anders
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Nuclear Receptor Function in Zebrafish
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390661/
https://ncbi.nlm.nih.gov/pubmed/30371853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy269
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