CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae

Pregnane X receptor (PXR; NR1I2) is a nuclear receptor that regulates transcriptional responses to drug or xenobiotic exposure, including induction of CYP3A transcription, in many vertebrate species. PXR is activated by a wide range of ligands that differ across species, making functional studies on...

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Udgivet i:Toxicol Sci
Main Authors: Salanga, Matthew C, Brun, Nadja R, Francolini, Rene D, Stegeman, John J, Goldstone, Jared V
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Emerging Technologies, Methods, and Models
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043230/
https://ncbi.nlm.nih.gov/pubmed/31868891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz246
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