Functional Characterization of a Full Length Pregnane X Receptor, Expression in vivo, and Identification of PXR Alleles in Zebrafish (Danio rerio)

The pregnane X receptor (PXR) (nuclear receptor NR1I2) is a ligand activated transcription factor, mediating responses to diverse xenobiotic and endogenous chemicals. The properties of PXR in fish are not fully understood. Here we report on cloning and characterization of full-length PXR of zebrafis...

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Detalhes bibliográficos
Main Authors: Bainy, Afonso C. D., Kubota, Akira, Goldstone, Jared V., Lille-Langøy, Roger, Karchner, Sibel I., Celander, Malin C., Hahn, Mark E., Goksøyr, Anders, Stegeman, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873750/
https://ncbi.nlm.nih.gov/pubmed/24121122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aquatox.2013.09.014
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