Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently

BACKGROUND: Many persistent organic pollutants (POPs) accumulate readily in polar bears because of their position as apex predators in Arctic food webs. The pregnane X receptor (PXR, formally NR1I2, here proposed to be named promiscuous xenobiotic receptor) is a xenobiotic sensor that is directly in...

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發表在:Toxicol Appl Pharmacol
Main Authors: Roger, Lille-Langøy, V, Goldstone Jared, Marte, Rusten, R, Milnes Matthew, Rune, Male, J, Stegeman John, Bruce, Blumberg, Anders, Goksøyr
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387200/
https://ncbi.nlm.nih.gov/pubmed/25680588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.02.001
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