Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA)

Peroxisome proliferator-activated receptor alfa (PPARA/NR1C1) is a ligand activated nuclear receptor that is a key regulator of lipid metabolism in tissues with high fatty acid catabolism such as the liver. Here, we cloned PPARA from polar bear liver tissue and studied in vitro transactivation of po...

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Publicat a:Sci Rep
Autors principals: Routti, Heli, Berg, Mari K., Lille-Langøy, Roger, Øygarden, Lene, Harju, Mikael, Dietz, Rune, Sonne, Christian, Goksøyr, Anders
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502799/
https://ncbi.nlm.nih.gov/pubmed/31061404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43337-w
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