Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA)

Peroxisome proliferator-activated receptor alfa (PPARA/NR1C1) is a ligand activated nuclear receptor that is a key regulator of lipid metabolism in tissues with high fatty acid catabolism such as the liver. Here, we cloned PPARA from polar bear liver tissue and studied in vitro transactivation of po...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Routti, Heli, Berg, Mari K., Lille-Langøy, Roger, Øygarden, Lene, Harju, Mikael, Dietz, Rune, Sonne, Christian, Goksøyr, Anders
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502799/
https://ncbi.nlm.nih.gov/pubmed/31061404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43337-w
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