Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA)

Peroxisome proliferator-activated receptor alfa (PPARA/NR1C1) is a ligand activated nuclear receptor that is a key regulator of lipid metabolism in tissues with high fatty acid catabolism such as the liver. Here, we cloned PPARA from polar bear liver tissue and studied in vitro transactivation of po...

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Udgivet i:Sci Rep
Main Authors: Routti, Heli, Berg, Mari K., Lille-Langøy, Roger, Øygarden, Lene, Harju, Mikael, Dietz, Rune, Sonne, Christian, Goksøyr, Anders
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502799/
https://ncbi.nlm.nih.gov/pubmed/31061404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43337-w
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