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A human post-catalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation
During exon ligation, the S. cerevisiae spliceosome recognizes the 3´-splice site (3´SS) of precursor mRNA through non-Watson-Crick pairing with the 5´SS and the branch adenosine, in a conformation stabilised by Prp18 and Prp8. Here we present the 3.3 Å cryoEM structure of a human post-catalytic spl...
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| Pubblicato in: | Science |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386133/ https://ncbi.nlm.nih.gov/pubmed/30705154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw5569 |
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