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Post-catalytic spliceosome structure reveals mechanism of 3'-splice site selection

Introns are removed from eukaryotic mRNA precursors by the spliceosome in two transesterification reactions – branching and exon ligation. The mechanism of 3'-splice site recognition during exon ligation has remained unclear. Here we present the 3.7Å cryo-EM structure of the yeast P complex spl...

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Udgivet i:Science
Main Authors: Wilkinson, Max E., Fica, Sebastian M., Galej, Wojciech P., Norman, Christine M., Newman, Andrew J., Nagai, Kiyoshi
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808836/
https://ncbi.nlm.nih.gov/pubmed/29146871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar3729
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