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Structure of a spliceosome remodelled for exon ligation
The spliceosome excises introns from pre-mRNAs in two sequential transesterifications – branching and exon ligation(1) – catalysed at a single catalytic metal site in U6 snRNA(2,)(3). The recent structures of the spliceosomal C complex(4,)(5) with the cleaved 5’-exon and lariat—3’-exon bound to the...
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| Publicado en: | Nature |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321579/ https://ncbi.nlm.nih.gov/pubmed/28076345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21078 |
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