FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy

Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed by insulin and thus are key mediators of insulin action. To study their role in diabetic muscle wasting, we crea...

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Détails bibliographiques
Publié dans:Diabetes
Auteurs principaux: O’Neill, Brian T., Bhardwaj, Gourav, Penniman, Christie M., Krumpoch, Megan T., Suarez Beltran, Pablo A., Klaus, Katherine, Poro, Kennedy, Li, Mengyao, Pan, Hui, Dreyfuss, Jonathan M., Nair, K. Sreekumaran, Kahn, C. Ronald
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2019
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385751/
https://ncbi.nlm.nih.gov/pubmed/30523026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0416
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