Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis

Gambogic acid (GA), a xanthonoid extracted from the resin of the tree, Garcinia hanburyi, was recently shown to exert anticancer activity in multiple studies, but the underlying action mechanism remains unclear. Here, we show that GA induces cancer cell death accompanied by vacuolation in vitro and...

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Pubblicato in:Cell Death Dis
Autori principali: Seo, Min Ji, Lee, Dong Min, Kim, In Young, Lee, Dongjoo, Choi, Min-Koo, Lee, Joo-Youn, Park, Seok Soon, Jeong, Seong-Yun, Choi, Eun Kyung, Choi, Kyeong Sook
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385239/
https://ncbi.nlm.nih.gov/pubmed/30796201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1360-4
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