Llwytho...

Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology

In Parkinson disease (PD), there is a preferential degeneration of neurons that contain the dark-brown cytoplasmic pigment neuromelanin, in particular dopaminergic neurons of the substantia nigra (SN), the loss of which leads to the typical motor symptoms of the disease and constitutes the cardinal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Autophagy
Prif Awduron: Vila, Miquel, Laguna, Ariadna, Carballo-Carbajal, Iria
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844506/
https://ncbi.nlm.nih.gov/pubmed/31480882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1659621
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!