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Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology

In Parkinson disease (PD), there is a preferential degeneration of neurons that contain the dark-brown cytoplasmic pigment neuromelanin, in particular dopaminergic neurons of the substantia nigra (SN), the loss of which leads to the typical motor symptoms of the disease and constitutes the cardinal...

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Publicado en:Autophagy
Autores principales: Vila, Miquel, Laguna, Ariadna, Carballo-Carbajal, Iria
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844506/
https://ncbi.nlm.nih.gov/pubmed/31480882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1659621
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