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Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology

In Parkinson disease (PD), there is a preferential degeneration of neurons that contain the dark-brown cytoplasmic pigment neuromelanin, in particular dopaminergic neurons of the substantia nigra (SN), the loss of which leads to the typical motor symptoms of the disease and constitutes the cardinal...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Autophagy
Päätekijät: Vila, Miquel, Laguna, Ariadna, Carballo-Carbajal, Iria
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844506/
https://ncbi.nlm.nih.gov/pubmed/31480882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1659621
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