Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

In Parkinson’s disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin accumulates with age, the latter being the main risk factor for PD. The contribution of neuromelanin to PD pathogenesis remains...

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Udgivet i:Nat Commun
Main Authors: Carballo-Carbajal, Iria, Laguna, Ariadna, Romero-Giménez, Jordi, Cuadros, Thais, Bové, Jordi, Martinez-Vicente, Marta, Parent, Annabelle, Gonzalez-Sepulveda, Marta, Peñuelas, Núria, Torra, Albert, Rodríguez-Galván, Beatriz, Ballabio, Andrea, Hasegawa, Takafumi, Bortolozzi, Analía, Gelpi, Ellen, Vila, Miquel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405777/
https://ncbi.nlm.nih.gov/pubmed/30846695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08858-y
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