Overexpression of TFEB Drives a Pleiotropic Neurotrophic Effect and Prevents Parkinson’s Disease-Related Neurodegeneration

The possible implication of transcription factor EB (TFEB) as a therapeutic target in Parkinson’s disease has gained momentum since it was discovered that TFEB controls lysosomal biogenesis and autophagy and that its activation might counteract lysosomal impairment and protein aggregation. However,...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Torra, Albert, Parent, Annabelle, Cuadros, Thais, Rodríguez-Galván, Beatriz, Ruiz-Bronchal, Esther, Ballabio, Andrea, Bortolozzi, Analía, Vila, Miquel, Bové, Jordi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986717/
https://ncbi.nlm.nih.gov/pubmed/29628303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.02.022
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