Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis

Gambogic acid (GA), a xanthonoid extracted from the resin of the tree, Garcinia hanburyi, was recently shown to exert anticancer activity in multiple studies, but the underlying action mechanism remains unclear. Here, we show that GA induces cancer cell death accompanied by vacuolation in vitro and...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Seo, Min Ji, Lee, Dong Min, Kim, In Young, Lee, Dongjoo, Choi, Min-Koo, Lee, Joo-Youn, Park, Seok Soon, Jeong, Seong-Yun, Choi, Eun Kyung, Choi, Kyeong Sook
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385239/
https://ncbi.nlm.nih.gov/pubmed/30796201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1360-4
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