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KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells

The nuclear import receptor karyopherin β1 (KPNB1) is involved in the nuclear import of most proteins and in the regulation of multiple mitotic events. Upregulation of KPNB1 has been observed in cancers including glioblastoma. Depletion of KPNB1 induces mitotic arrest and apoptosis in cancer cells,...

詳細記述

保存先:
書誌詳細
出版年:Oncogene
主要な著者: Zhu, Zhi-Chuan, Liu, Ji-Wei, Li, Kui, Zheng, Jing, Xiong, Zhi-Qi
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5978811/
https://ncbi.nlm.nih.gov/pubmed/29520102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0180-9
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